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Apexbio Technology LLC AMG-208 1002304-34-8 5mg
Supplier: Apexbio Technology LLC A11865
AMG-208 (CAS 1002304-34-8) is a highly selective small molecule inhibitor of the receptor tyrosine kinase c-Met which is the endogenous receptor for hepatocyte growth factor (HGF) and is involved in cellular processes such as proliferation migration and invasion AMG-208 exhibits potent c-Met inhibition with an IC50 of 9 3 nM in enzymatic assays and effectively blocks HGF-induced c-Met phosphorylation in PC3 cells with an IC50 of 46 nM In human liver microsome studies AMG-208 showed time-dependent inhibition of CYP3A4 activity Pharmacokinetic evaluation in rats demonstrated high bioavailability and a moderate elimination half-life Dysregulation of c-Met has been implicated in multiple human cancers supporting AMG-208 s utility as a research tool in oncology
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