Apexbio Technology LLC AMG 337 1173699-31-4 25mg

Supplier:  Apexbio Technology LLC B619325

AMG 337 (CAS 1173699-31-4) is a potent and selective inhibitor of the MET receptor tyrosine kinase which mediates cellular processes such as survival proliferation and invasion Dysregulation of MET signaling is implicated in various human cancers In enzyme assays AMG 337 exhibits an IC50 below 5 nM against MET It demonstrates high selectivity for MET over a panel of more than 400 kinases and lipid kinases In vitro AMG 337 inhibits HGF-induced MET phosphorylation and selectively reduces viability in gastric cancer cell lines with MET gene amplification (IC50 50 nM 10 M in non-amplified lines) In vivo oral administration shows dose-dependent tumor growth inhibition in MET-amplified xenograft models AMG 337 is under clinical evaluation for safety and pharmacokinetics in solid tumor patients

Catalog No. 50-000-92248