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Apexbio Technology LLC Amiodarone HCl 19774-82-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B13895.1
Amiodarone HCl (CAS 19774-82-4) is a small-molecule antagonist targeting adrenergic receptors It is designed to non-competitively inhibit adrenergic agonist-mediated responses thereby modulating cardiac and arterial adrenergic signaling Amiodarone HCl exerts its biological activity primarily through non-competitive antagonism of chronotropic responses induced by 1-adrenoreceptor agonist isoproterenol and inhibition of -adrenoreceptor-mediated norepinephrine-induced contractions In ex vivo cardiac and arterial tissue studies Amiodarone HCl demonstrates non-competitive inhibition with inhibitory constants (pD ) of approximately 4 17 for isoproterenol and 4 06 for norepinephrine Based on these pharmacological properties Amiodarone HCl holds research potential in studies of autonomic receptor-related cardiovascular mechanisms
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