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Medchemexpress LLC Amrubicin hydrochloride | 110311-30-3 | 98.78% | C25H26ClNO9 | 5 MG
Supplier: Medchemexpress LLC HYB0067A5MG
Amrubicin hydrochloride (SM-5887) is a DNA topoisomerase II inhibitor used for cancer research. It exhibits radio-enhancement effects on human lung adenocarcinoma A549 cells and suppresses various other cell lines. It also induces apoptosis in U937 cells and demonstrates significant antitumor activities against SCLC tumors in vivo.
- DNA topoisomerase II inhibitor.
- Used for research of cancer.
- Exhibits radio-enhancement effects on human lung adenocarcinoma A549 cells.
- Suppresses LX-1, A549, A431, and BT-474 cell lines.
- Induces apoptosis in U937 cells and activates caspase-3/7.
- Reduces mitochondrial membrane potential (Δψm).
- Demonstrates significant antitumor activities against SCLC tumors.
- In combination with cisplatin and irinotecan, it significantly inhibits tumor growth.
- Suppresses tumor growth in human cancer xenograft models.
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