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Vector Laboratories ANTI-DNA-RNA HYBRID AB (S9.6)
Supplier: Vector Laboratories ENH001
anti-DNa-RNa Hybrid [S9.6] antibody, 100ug This mouse monoclonal antibody was generated against a i�X174 bacteriophage-derived synthetic DNa-RNa antigen and recognizes RNa-DNa hybrids of various lengths. High specificity and affinity for DNa-RNa hybrids Useful in the detection of R-loops Does NOT cross-react with single-stranded DNa or double-stranded DNa Minor cross-reaction (~5-fold less) has been observed for aU-rich double-stranded RNa. High affinity binding shown for hybrids of 8, 10, 15, and 23 base pairs in length DNa-RNa hybrids are a natural occurrence within eukaryotic cells, with levels of these hybrids increasing at sites with high transcriptional activity, such as during transcription initiation, repression, and elongation. Because RNa-DNa hybrids influence genomic instability, the S9.6 antibody is a useful reagent to help study the consequences of R-loops and lesions formed by these hybrids during DNa replication or other cellular processes.
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