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Bio X Cell Monoclonal Antibody, anti-mouse CTLA-4 (CD152), Clone 9D9, Mouse IgG2b
Supplier: Bio X Cell BE0164R050MG
The 9D9 monoclonal antibody targets mouse CTLA-4 (CD152), a 33 kDa cell surface receptor on activated T and B lymphocytes. CTLA-4 negatively regulates cell-mediated immune responses and plays roles in immunological tolerance and protective immunity. As a target for cancer treatment through immune checkpoint blockade, the 9D9 antibody is used in blocking/neutralization experiments and causes intra-tumoral regulatory T cell depletion.
- Host: Mouse
- Isotype: Mouse IgG2b
- Reacts with: Mouse
- Formulation: PBS, pH 7.0, without stabilizers or preservatives
- Endotoxin: ≤1 EU/mg
- Purity: ≥95%
- Sterility: 0.2 µm filtration
- Applications: In vivo CTLA-4 neutralization, western blot, in vivo intra-tumoral regulatory T cell depletion, in vitro organoids/organ-on-chip
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