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Cayman Chemical ANTIBODY 4u8C 25mg

Supplier: Cayman Chemical 2211025 MG
An IRE1α inhibitor; inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM); reduces Erdj4 gene expression downstream of IRE1α and Xbp1 (IC50 = 3.4 µM); does not block IRE1α autophosphorylation; reduces IL-4 production in CD4+ T cells; reduces LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion
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