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Cayman Chemical ANTIBODY A-841720 1mg
Supplier: Cayman Chemical 218071 MG
A noncompetitive antagonist of mGluR1 (IC50 = 10.7 nM); selective over mGluR5 (IC50 = 343 nM), mGluR2, mGluR4, and mGluR7; selective over a panel of other G-coupled protein receptors as well as ligand- and voltage-gated ion channels at a concentration of 10 µM; dose-dependently inhibits complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 µmol/kg) and sciatic nerve injury-induced mechanical allodynia (ED50 = 28 µmol/kg) in rats; enhances cocaine seeking in mice after a prolonged abstinence following a single conditioning session (10 mg/kg)
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