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Cayman Chemical ANTIBODY ABP 688 500ug
SDP

Supplier:  Cayman Chemical 30929500 UG

Encompass_Preferred

A non-competitive antagonist of mGluR5 (Ki = 3.5 nM in a radioligand binding assay using L(tk-) cell membranes expressing human receptors); binds at an allosteric binding site; selective for mGluR5 receptors over a panel of CNS G protein-coupled receptors, ion channels, and transporters at 10 μM; inhibits quisqualate-induced phosphoinositol accumulation in and glutamate-induced calcium release from L(tk-) cells expressing human mGluR5 (IC50s = 2.4 and 2.3 nM, respectively); radiolabeled forms have been used as PET tracers for in vivo imaging of mGluR5 receptors in rodents

Catalog No. 50-298-8456


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