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Cayman Chemical ANTIBODY ABX-1431 50mg
Supplier: Cayman Chemical 2602350 MG
An inhibitor of MAGL (IC50s = 14 and 27 nM for human and rat enzyme, respectively); selective for MAGL over ABHD6 and PLA2G7 (IC50s = 2.7 and >10 μM, respectively), as well as a panel of 33 serine hydrolases and a panel of 95 enzymes, receptors, transporters, and ion channels at 10 μM; selective for MAGL over CYP1A2, CYP2C9, CYP2C19, and CYP3A4/5 (IC50s = >50 μM); inhibits MAGL activity in mouse and rat brain ex vivo (ED50s = 1.4 and 0.5 mg/kg, respectively); decreases brain levels of 2-AG in mice and rats; reduces formalin-induced paw-licking time in rats
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