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Cayman Chemical ANTIBODY ACPT-I 10mg
Supplier: Cayman Chemical 7801010 MG
An mGluR4a and mGluR8 agonist (EC50s = 7.2 and 8.2 µM, respectively); has no effect on mGluR1a or mGluR2; reduces cell death following oxygen-glucose deprivation in primary neuronal cultures using concentrations of 1-200 µM; reduces cell death in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg; reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.); has anxiolytic-like effects in mice and rats that can be blocked by 5-HT1A and GABAA receptor antagonists
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