Cayman Chemical ANTIBODY ADU-S100 500ug

Supplier:  Cayman Chemical 27901500 UG

A cyclic dinucleotide STING agonist; induces IFN-β-dependent reporter activity in HEK293T cells expressing human STING, the human STING variants STING HAQ, STING REF, STING AQ, STING Q, or mouse STING at 10 µM; reduces tumor growth in wild-type, but not in Sting1-/-, mice in a B16/F10 murine melanoma model when intratumorally administered at 50 UG/tumor per day for three days; decreases primary and secondary tumor volume in a 4T1 murine breast cancer model of tumor rechallenge when intratumorally administered; unilateral intratumoral administration of ADU-S100 reduces tumor volumes in a bilateral CT26 murine colorectal cancer model; increases tumor infiltration of NK cells, CD4+ T cells, and CD8+ T cells , as well as increases immune cell-induced tumor necrosis, in a GL261 murine glioma model when intratumorally administered at 50 UG/tumor

Catalog No. 50-294-0224