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Cayman Chemical ANTIBODY AIM 100 10mg
Supplier: Cayman Chemical 2948710 MG
An ACK1/TNK2 inhibitor (IC50 = 21.58 nM); selective for ACK1/TNK2 over Abl1, BTK, LCK, and LYN (IC50s = 705.9, 871.7, 432.3, and 346.7 nM, respectively), as well as a panel of 25 additional kinases; inhibits EGF-induced increases in ATM protein levels, ACK1/TNK2 and androgen receptor phosphorylation, and pTyr267-androgen receptor binding to the ATM enhancer in LAPC4 cells at 1 μM; inhibits the growth of LNCaP and LAPC4 cells in a concentration-dependent manner and induces cell cycle arrest at the G0/G1 phase at 3 μM; enhances radiation-induced tumor growth reduction in an LNCaP-caAck CRPC mouse xenograft model at 4 mg/kg
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