Cayman Chemical ANTIBODY APS6-45 5mg

Supplier:  Cayman Chemical 384175 MG

An inhibitor of RETM918T and a derivative of sorafenib; selectively binds to RETM918T over EphA8, p38δ, JNK2, and c-Src (Kds = 28, 410, 940, 1,500, and 1,700 nM, respectively) and a panel of over 60 kinases at 10 µM, but also selectively binds to Cdk14, MAP4K4, and PTK5 (Kds = 55, 130, and 140 nM, respectively); inhibits TT cell colony formation at 30 nM; decreases tumor volume in a TT mouse xenograft model at 10 mg/kg per day; increases survival to adulthood in transgenic Drosophila expressing the lethal RetM955T mutation in a concentration-dependent manner; prevents the development of a rough-eye phenotype induced by RetM955T in transgenic Drosophila at 100 µM;

Catalog No. 50-291-9139