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Cayman Chemical ANTIBODY ARN726 1mg
Supplier: Cayman Chemical 242591 MG
An NAAA inhibitor (IC50s = 27 and 63 nM for the human and rat enzyme, respectively); selective for NAAA over FAAH and acid ceramidase (IC50s = >100 and 12.5 μM, respectively), as well as a panel of 28 enzymes at 10 μM; decreases lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation from 1-30 mg/kg; inhibits NAAA and reverses complete Freund's adjuvant-induced decreases in PEA and OEA levels in inflamed paw tissue in a rat model of arthritis
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