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Cayman Chemical ANTIBODY ARN810 1mg
SDP

Supplier:  Cayman Chemical 295951 MG

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A SERD; binds to ERα and ERβ (IC50s = 6.1 and 8.8 nM, respectively); induces degradation of ERα in MCF-7 cells (EC50 = 0.7 nM); inhibits 17β-estradiol-induced ERα transcriptional activity in a reporter assay and reduces MCF-7 breast cancer cell viability (IC50 = 2 nM); inhibits 17β-estradiol-induced uterine weight gain in rats at 1 mg/kg; reduces tumor volume in tamoxifen-sensitive and -resistant MCF-7 mouse xenograft models

Catalog No. 50-298-8502


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