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Cayman Chemical ANTIBODY AVN-492 10mg
Supplier: Cayman Chemical 2807910 MG
An antagonist of the 5-HT6 receptor (Ki = 0.09 nM); selectively inhibits the 5-HT6 receptor over the 5-HT2B receptor (IC50s = 0.19 and 268 nM, respectively, in a radioligand binding assay); inhibits increases in cAMP levels induced by 5-HT in HEK293 cells expressing the 5-HT6 receptor (IC50 = 1.5 nM); increases the time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic activity, at 0.2 mg/kg; prevents memory deficits induced by MK-801 in a passive avoidance test at 1 mg/kg
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