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Cayman Chemical ANTIBODY AZD 8797 1mg
Supplier: Cayman Chemical 284191 MG
A CX3CR1 antagonist (Ki = 3.9 nM); selective for CX3CR1 over CX3CR2 (Ki = 2,800 nM); inhibits CX3CL1-induced [35S]GTPγS accumulation in CHO cell membranes expressing human CX3CR1 from 0.1-10 µM; inhibits adhesion of RBMI-8226 cells to CX3CL1 (IC50 = 5.8 nM); reduces spinal cord inflammation and demyelination, as well as the incidence of disease relapse, in a rat model of myelin oligodendrocyte glycoprotein-induced EAE at 39 and 78 µmol/kg per day
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