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Cayman Chemical ANTIBODY AZD 8835 10mg
Supplier: Cayman Chemical 2916610 MG
An inhibitor of PI3Kα and PI3Kδ (IC50s = 6.2 and 5.7 nM, respectively); selective for PI3Kα and PI3Kδ over PI3Kβ and PI3Kγ (IC50s = 431 and 90 nM, respectively); inhibits Akt phosphorylation in PIK3CA constitutively active mutant BT474 cells and Jeko-1 B cells that express endogenous PI3Kδ (IC50s = 57 and 49 nM, respectively); reduces tumor growth and Akt phosphorylation in an SKOV3 mouse xenograft model at 25 mg/kg; increases the activity of CD8+ effector T cells and reduces tumor growth in a C26 mouse syngeneic tumor model
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