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Cayman Chemical ANTIBODY BI-749327 1mg
Supplier: Cayman Chemical 396721 MG
A TRPC6 inhibitor (IC50 = 13 nM for the mouse channel); selective for TRPC6 over TRPC3 and TRPC7 (IC50s = 1,100 and 550 nM, respectively, for the mouse channels); inhibits TRPC6-mediated reporter gene expression in HEK293T cells expressing mouse TRPC6 at 100, 250, and 500 nM; decreases myocardial interstitial fibrosis in a mouse model of hypertrophic cardiomyopathy induced by transaortic constriction at 30 mg/kg; reduces unilateral ureteral obstruction-induced renal fibrosis in mice; increases survival, decreases myocardial fibrosis, and improves grip strength in a mouse model of DMD at 30 mg/kg
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