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Cayman Chemical ANTIBODY CCT241736 25mg
Supplier: Cayman Chemical 2618525 MG
A dual inhibitor of Aurora kinase (Kds = 7.5 and 48 nM for Aurora A and B, respectively) and FLT3 (Kds = 6.2, 38, and 14 nM for wild-type, FLT3ITD, and FLT3D835Y, respectively); inhibits the activity of 22 additional kinases by >90% in a panel of 386 nonmutant kinases at 1 µM; inhibits cell growth of SW620, HCT116, MOLM-13, and MV4-11 cancer cells (GI50s = 1, 0.3, 0.1, and 0.3 µM, respectively); oral administration reduces tumor growth by 58% in an MV4-11 mouse xenograft model at 50 mg/kg
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