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Cayman Chemical ANTIBODY CDKI-73 5mg
Supplier: Cayman Chemical 410995 MG
An inhibitor of Cdk9/cyclin T1, Cdk1/cyclin B, and Cdk2/cyclin A complexes (Kis = 4, 4, and 3 nM, respectively); selective for these complexes over the Cdk7/cyclin H complex (Ki = 91 nM); cytotoxic to HCT116 cells (GI50 = <10 nM); induces apoptosis in COLO 205, HCT116, HT-29, and KM12 cells at 0.25 or 1 µM; reduces the levels of Bcl-2, cyclin D1, and Mcl-1, as well as decreases the mitochondrial membrane potential, in HCT116 cells at 0.25 µM; decreases tumor volume in an HCT116 mouse xenograft model at 100 mg/kg every three days
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