Cayman Chemical ANTIBODY CIM0216 1mg

Supplier:  Cayman Chemical 276841 MG

A TRMP5 activator; induces inward and outward rectifying currents in TRPM3-expressing HEK293 cells voltage-clamped at ±80 mV at 1 µM; selective for TRMP3 over TRPM1, TRPM4, TRPM6, and TRMP7 in HEK293 cells expressing the human channels, but does activate TRPA1 by 15% in CHO cells expressing mouse TRPA1 at 10 µM; inhibits ADP-ribose-induced TRPM2, calcium-induced TRMP5, and methanol-induced TRPM8 activation by 17, 34, and 61%, respectively, in HEK293 cells expressing the human channels at 10 µM; stimulates insulin and CGRP release in isolated mouse pancreatic islets and skin nerve terminals, respectively, from 5-100 µM; induces activation of AP-1, c-Jun, and c-fos in HEK293 cell reporter assays at 20 µM

Catalog No. 50-294-0708