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Cayman Chemical ANTIBODY CZ415 10mg
Supplier: Cayman Chemical 2766810 MG
An mTOR inhibitor (Kd = 6.3 nM); 1,000-fold selective for mTOR over a panel of 285 kinases; inhibits phosphorylation of S6RP and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively); inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM); reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis at 10 mg/kg; inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model at 20 mg/kg
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