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Cayman Chemical ANTIBODY d-1001b 10mg
Supplier: Cayman Chemical 3148810 MG
An inhibitor of mutant IDH1 (IC50s = 15 and 130 nM for IDH1R132H and IDH1R132C, respectively); selective for mutant IDH1 over wild-type IDH1 and IDH2, as well as IDH2R140Q and IDH2R172Q (IC50s = >10,000 nM for all); inhibits 2-HG production in TF-1 cells stably transfected with IDH1R132H or IDH1R132C (IC50s = 29 and 35 nM, respectively) and in 293A cells transiently transfected with IDH1R132H or IDH1R132C (IC50s = 29 and 42 nM, respectively); reduces tumor growth, as well as intratumoral and plasma 2-HG levels, in a subcutaneous IDH1R132H-expressing A1074 PDX mouse model of glioblastoma
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