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Cayman Chemical ANTIBODY DL-TBOA 5mg
Supplier: Cayman Chemical 296325 MG
An EAAT inhibitor (IC50s = 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively); inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV; increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus at 500 μM; increases lesion volume in the rat hippocampal CA1 region when administereed intrahippocampally; induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges in rats at 25 nmol; induces antinociception in the second phase of the formalin test in rats at 5 and 10 μg when administered 10 minutes prior to formalin
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