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Cayman Chemical ANTIBODY DnIrIxIn 1mg
Supplier: Cayman Chemical 209801 MG
A CXCR2 antagonist (IC50 = 12.5 µM); selective for CXCR2 over CXCR1 (IC50 = 977 nM); inhibits IL-8-induced calcium mobilization in CHO-K1 cells expressing human CXCR2 (pA2 = 7.52); inhibits neutrophil surface expression of CD11b in isolated rat whole blood (IC50 = 890 nM); reduces BALF neutrophil infiltration in rat models of LPS- or ozone-induced pulmonary neutrophilia (ED50s = 1.4 and 16 mg/kg, respectively)
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