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Cayman Chemical ANTIBODY EmrIcasn 25mg
Supplier: Cayman Chemical 2220425 MG
A pan-caspase inhibitor; prevents cold ischemia-warm reperfusion-induced SEC apoptosis and inhibits caspase-3 activation in rat liver at 10 mg/kg ex vivo; reduces ALT levels (ED50s = <0.01-0.38 mg/kg) as well as apoptosis and caspase activity in a dose-dependent manner in the α-Fas mouse and D-Gln/LPS rat models of liver injury; reduces caspase-3 and caspase-8 activity, serum ALT levels, hepatocyte apoptosis, and hepatic fibrogenesis in a mouse model of high-fat diet-induced NASH; enhances islet engraftment and lowers post-transplant fasting glucose levels in a porcine islet autotransplant model
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