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Cayman Chemical ANTIBODY ERB 041 5mg
Supplier: Cayman Chemical 287375 MG
An ERβ agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively); selective for ERβ over ERα (IC50s = 1,200, 620, and 750 nM for the human, rat, and mouse ERα, respectively); induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERβ (EC50 = 20 nM); inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease at 0.1 and 0.3 mg/kg; reduces joint swelling in a rat model of adjuvant-induced arthritis at 1 mg/kg; reduces lesion formation in a mouse model of endometriosis at 10 mg/kg
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