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Cayman Chemical ANTIBODY ETP-46321 25mg
SDP

Supplier:  Cayman Chemical 3733025 MG

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A PI3K p110α and p110δ inhibitor (apparent Kis = 2.3 and 14.2 nM, respectively); selective for PI3K p110α and p110δ over p110β and p110γ (apparent Kis = 170 and 179 nM, respectively), as well as a panel of 288 kinases at 1 µM; inhibits Akt phosphorylation in U2OS cells (IC50 = 8.3 nM); reduces tumor volume in a K-RasG12V-driven murine lung tumor model at 50 mg/kg; reduces anti-collagen IgG1 and IgG2a production, swelling, and joint rigidity in a mouse model of collagen-induced arthritis

Catalog No. 50-291-7959


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