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Cayman Chemical ANTIBODY FluzoparIb 5mg
Supplier: Cayman Chemical 366715 MG
A PARP1 inhibitor (IC50 = 1.46 nM); induces DNA double-strand breaks in wild-type, but not BRCA2-/-, V-C8 cells, as well as BRCA1-/- MDA-MB-436 cells at 1 and 10 µM; inhibits the proliferation of BRCA2-/- V-C8 cells (IC50 = 0.053 µM), BRCA1-/- MDA-MB-436, UWB1.289, and MX-1 cells (IC50s = 0.51, 1.57, and 1.57 µM, respectively), and OVCAR-8 cells containing hypermethylated BRCA1 (IC50 = 1.43 µM); reduces tumor formation in an MDA-MB-436 mouse xenograft model at 1 and 3 mg/kg
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