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Cayman Chemical ANTIBODY GSK256066 25mg
SDP

Supplier:  Cayman Chemical 2801225 MG

Encompass_Preferred

A potent PDE4 inhibitor (IC50s = 4.9, 3.2, 3.8, and 1.1 pM for PDE4A, PDE4B, PDE4C, and PDE4D, respectively); >380,000-fold selective for PDE4 over PDE1-3, -5, and -6 and >2,500-fold selective over PDE7; inhibits LPS-induced TNF-α production in human peripheral blood monocytes (IC50 = 0.01 nM) and human whole blood (IC50 = 126 pM); intratracheal adminstration inhibits LPS-induced pulmonary neutrophilia in rats (ED50 = 1.1 UG/kg); inhibits ovalbumin-induced pulmonary eosinophilia in rats (ED50 = 0.4 UG/kg) and LPS-induced pulmonary neutrophilia in ferrets (ED50 = 18 UG/kg)

Catalog No. 50-294-1434


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