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Cayman Chemical ANTIBODY GSK5182 10mg
Supplier: Cayman Chemical 1909710 MG
An ERRγ inverse agonist (IC50 = 77 nM in a reporter assay); selectively binds to ERRγ over ERα, ERRα, and ERRβ (IC50s = 0.11, 2, >10, and >10 µM, respectively); enhances radioiodine uptake and NIS membrane localization in BHT-101 and CAL-62 anaplastic thyroid cancer cells; inhibits osteoclastogenesis induced by RANKL and M-CSF in primary mouse BMDMs and induces apoptosis in osteoclasts at 10 µM; inhibits ACEA-induced fibrinogen secretion in AML12 hepatocytes at 10 µM; decreases blood glucose levels in a pyruvate tolerance test in a mouse model of high-fat diet-induced obesity at 40 mg/kg
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