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Cayman Chemical ANTIBODY ICA 069673 50mg
Supplier: Cayman Chemical 2299550 MG
A Kv7 channel activator; selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner; has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM); increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively)
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