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Cayman Chemical ANTIBODY ImazalIl 50mg
Supplier: Cayman Chemical 2581550 MG
An imidazole fungicide that inhibits ergosterol biosynthesis; inhibits the growth of various fungi in vitro including P. italicum, A. niger, U. maydis, B. alii, and C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7); inhibits S. cerevisiae, but not rat liver microsomal, CYPs (IC50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC50 = 0.34 μM); activates the murine PXR in a concentration-dependent manner in a cell-based reporter assay; increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice at 100 mg/kg; increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the mCAR agonist TCPOBOP
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