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Cayman Chemical ANTIBODY IMR-1 25mg

Supplier: Cayman Chemical 2792025 MG
An inhibitor of Maml1 recruitment to chromatin; binds to the intracellular domain of Notch (KD = 11 µM) and prevents transcription of Notch target genes by inhibiting the recruitment of Maml1 to chromatin; inhibits colony formation in Notch-dependent cell lines but not Notch-independent cell lines at 15 and 45 µM; decreases the expression of Notch target genes and reduces tumor growth in a patient-derived esophageal adenocarcinoma mouse xenograft model at 15 mg/kg
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