Cayman Chemical ANTIBODY INCB 3344 5mg

Supplier:  Cayman Chemical 284335 MG

An antagonist of CCR2 (IC50 = 10 nM); selective for CCR2 over a panel of G protein-coupled receptors, including CCR1 and CCR5, with IC50s values >1 µM; inhibits MCP-1-induced chemotaxis of WEHI-274 cells (IC50 = 10 nM); inhibits monocyte influx in a thioglycolate-induced mouse model of peritonitis at 60 and 100 mg/kg; decreases the expression of CCR2 mRNA in the EAr and reduces EAr swelling in a mouse model of delayed-type hypersensitivity reaction at 30, 50, and 100 mg/kg twice per day; prevents increases in or reduces macrophage levels in the spinal cord at 100 mg/kg per day beginning the day of immunization or seven days following immunization, respectively, in a mouse model of EAE

Catalog No. 50-294-0879