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Cayman Chemical ANTIBODY K-TMZ 5mg
Supplier: Cayman Chemical 270225 MG
A DNA alkylating agent; increases the concentration of O6-methylated deoxyguanosine in U87 GBM cells in a concentration-dependent manner; reduces cell viability in GBM cell lines lacking (IC50s = 18-44 μM) or expressing MGMT (IC50s = 115-240 μM); can cross the blood-brain barrier; increases survival in a Br23c mouse xenograft model of GBM at 14.9 mg/kg
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