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Cayman Chemical ANTIBODY K858 25mg

Supplier: Cayman Chemical 2211225 MG
An inhibitor of Eg5 (IC50 = 1.3 µM); inhibits growth (GI50 = 0.98 µM), induces mitotic arrest (EC50 = 1.6 µM), and activates caspase-3 (EC50 = 1.6 µM) in HCT116 cells; selectively induces mitotic cell death in HCT116 cells over non-cancerous ARPE-19 retinal pigment epithelial cells; reduces tumor growth in an A2780 ovarian cancer mouse xenograft model at 150 mg/kg
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