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Cayman Chemical ANTIBODY L-006 235 10mg
Supplier: Cayman Chemical 2884310 MG
An orally bioavailable reversible inhibitor of cathepsin K (Ki(app) = 0.2 nM); selective for cathepsin K over cathepsins B, -L, and -S (Ki(app) = 1, 6, and 47 µM, respectively); inhibits degradation of bovine bone by isolated rabbit osteoclasts (IC50 = 5 nM); reduces loss of lumbar vertebral bone mineral density by 13.3% in ovariectomized rabbits at 10 mg/kg for 27 days; increases weight bearing, indicating analgesia, in a rat model of osteoarthritis pain at 100 mg/kg
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