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Cayman Chemical ANTIBODY L-778 123 5mg
SDP

Supplier:  Cayman Chemical 325045 MG

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A dual inhibitor of FTase and GGTase I (IC50s = 2 and 98 nM, respectively); inhibits prenylation of FTase and GGTase I substrates HDJ2 and Rap1a in PSN-1 pancreatic tumor cells (EC50s = 92 and 6,760 nM, respectively); inhibits prenylation of the oncogenic protein Ki-Ras in PSN-1 cells in a concentration-dependent manner; reduces HDJ2 and Rap1a prenylation ex vivo in dog PBMCs when administered at a dose of 35-50 mg/kg per day; has no effect on Ki-Ras prenylation in patient-derived PBMCs; inhibits lectin-induced expression of the T cell activation markers CD71 and CD25 on human PMBCs (IC50s = 6.48 and 84.1 μM, respectively); inhibits IL-2-induced proliferation of CTLL2 cells (IC50 = 0.81 μM)

Catalog No. 50-294-6592


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