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Cayman Chemical ANTIBODY L67 50mg
Supplier: Cayman Chemical 2294150 MG
A competitive inhibitor of DNA ligases (IC50s = 10 and 10 µM for human DNA ligase I and human DNA ligase IIIβ); blocks DNA binding (Ki = 10 µM), increasing the cytotoxicity of DNA-damaging agents; inhibits mitochondrial DNA ligase IIIα and induces the production of ROS and apoptosis in cancerous, but not non-malignant, cells; does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 µM; cytotoxic in vitro
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