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Cayman Chemical ANTIBODY LOXO-292 10mg
SDP

Supplier:  Cayman Chemical 3351510 MG

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A RET kinase inhibitor; inhibits phosphorylation of a KIF5B-RET fusion protein expressed in HEK293 cells (IC50 = 4 nM); selectively inhibits proliferation of cancer cells containing RET mutations or gene fusions, including RETM918T-containing MZ-CRC-1 medullary thyroid and CCDC6-RET gene fusion-positive TPC-1 thyroid cancer cells, by 20 to 1,700-fold; improves survival in a CCDC6-RET gene fusion positive orthotopic PDX mouse model of brain cancer at 30 mg/kg

Catalog No. 50-294-9502


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