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Cayman Chemical ANTIBODY MBQ-167 1mg
Supplier: Cayman Chemical 354371 MG
A dual inhibitor of Rac and Cdc42 (IC50s = 103 and 78 nM, respectively); reduces Rac and Cdc42 GTP-binding and GTPase activity and limits migration and mammosphere formation in MDA-MB-231 cells at 250 nM; reduces cell viability and induces apoptosis at 250 nM in lapatinib-resistant SK-BR-3 and MDA-MB-435 cells alone or with lapatinib; reduces growth rates, axial budding, and Cdc42 activity in S. cerevisiae at 200 µM; reduces tumor growth in an MDA-MB-435 mouse xenograft model at 1 or 10 mg/kg three times per week, i.p.
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