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Cayman Chemical ANTIBODY NIcorndIl 100mg
Supplier: Cayman Chemical 18460100 MG
A SUR2B/Kir6.2 activator (EC50 = ~10 µM) and nitric oxide donor; selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM); activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 = 4.4 µM); decreases mean blood pressure, coronary resistance, and heart rate, as well as increases coronary sinus outflow, in dogs at 1 mg/kg i.v.; increases survival and decreases infarct size in a rabbit model of left coronary artery occlusion-induced myocardial ischemia-reperfusion injury
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