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Cayman Chemical ANTIBODY nratInIb 25mg
Supplier: Cayman Chemical 1840425 MG
A dual inhibitor of EGFR and HER2 (IC50s = 92 and 59 nM, respectively); selective for EGFR and HER2 over a panel of 12 kinases (IC50s = >5,000 nM) but does inhibit VEGFR2 and Src (IC50s = 800 and 1,400 nM, respectively); inhibits the proliferation of NCI H508 colorectal cancer cells expressing wild-type or mutant forms of HER2 (IC50s = 0.2-3 nM); reduces tumor growth in BT474 breast and SKOV3 ovarian cancer mouse xenograft models at 40 mg/kg
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