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Cayman Chemical ANTIBODY NVP-CGM097 1mg
Supplier: Cayman Chemical 295191 MG
An inhibitor of the MDM2-p53 interaction (IC50 = 1.7 nM for human MDM2 in a TR-FRET assay); selective for human MDM2 (Ki = 1.3 nM) over dog, mouse, and rat Mdm2 (Kis = 20.5, 65.9, and 47.4 nM, respectively); selectively inhibits proliferation of AML cells expressing wild-type p53 (IC50s = 50-1,000 nM) over AML cells expressing mutant p53 (IC50s = >1,000 nM); induces tumor regression in a PDX mouse model of AML at 100 mg/kg per day
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