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Cayman Chemical ANTIBODY ORY-1001 5mg
Supplier: Cayman Chemical 191365 MG
An LSD1 inhibitor (IC50 = 0.018 µM); selective for LSD1 over LSD2, MAO-A, and MAO-B (IC50s = >100 µM) but does inhibit spermine oxidase (IC50 = 7.4 µM); inhibits the imidazoline I2 receptor, norepinephrine and dopamine transporters, and L-type voltage-gated calcium channels (IC50s = 0.37, 2.4, 1.7, and 4.9 µM, respectively); induces accumulation of H3K4me2 in THP-1 cells (EC50 = 0.0022 µM); reduces viability in a panel of primary AML cells at 100 nM; increases survival in a PDX mouse model of T-ALL at 0.0125 mg/kg
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