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Cayman Chemical ANTIBODY OTS514 5mg
Supplier: Cayman Chemical 170535 MG
An inhibitor of TOPK (IC50 = 2.6 nM); selectively inhibits growth of patient-derived AML cells over normal CD34+ cells; inhibits growth of small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM); increases survival in a peritoneal mouse dissemination model of ovarian cancer at 25 and 50 mg/kg; dose-dependently inhibits tumor growth in an A549 mouse xenograft model at 1, 2.5, and 5 mg/kg
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