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Cayman Chemical ANTIBODY P22077 10mg
Supplier: Cayman Chemical 2370410 MG
A dual inhibitor of USP7 and USP47 (EC50s = 8.01 and 8.74 µM, respectively); selective for USP7 and USP47 over other USPs and proteases with EC50 values greater than 50 µM; induces the accumulation of polyubiquitinated proteins in HEK293 cells when used at a concentration of 25 µM; amplifies the cytotoxicity and p53-mediated apoptosis of doxorubicin of doxorubicin and etoposide in neuroblastoma cells when used at concentrations of 10 and 20 µM; inhibits tumor growth in neuroblastoma mouse xenograft models when administered at a dose of 20 mg/kg per day
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